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Information About Medication-Assisted Treatment (MAT)

Medication- Assisted Treatment (MAT) is the use of medications in combination with counseling and behavioral therapies, which is effective in the treatment of Opioid Use Disorders (OUD) and can help some people to sustain recovery.

More must be done to facilitate treatment options and the development of therapies to address OUD as a chronic disease with long-lasting effects. This means helping more people secure Medication-Assisted Treatment. It also requires us to find new and more effective ways to advance the use of medical therapy for the treatment of OUD.

FDA-Approved Medications for OUD Treatment

There are three drugs approved by the FDA for the treatment of opioid dependence:

  • Buprenorphine: This medicine helps reduce the craving for opioids and eases withdrawal symptoms, like feeling sick or shaky. You can get it from a regular doctor’s office.
  • Methadone: Methadone also helps cut cravings and makes withdrawal easier to handle. However, you usually need to go to a special clinic to get it.
  • Naltrexone: Naltrexone blocks the feeling of getting “high” from opioids. It’s often given as a monthly shot.

All three of these treatments have been demonstrated to be safe and effective in combination with counseling and psychosocial support.

MAT Personalized Treatment Plans

Everyone who seeks treatment for an OUD should be offered access to all three options as this allows providers to work with patients to select the treatment best suited to an individual’s needs. Due to the chronic nature of OUD, the need for continuing MAT should be re‐evaluated periodically. There is no maximum recommended duration of maintenance treatment, and for some patients, treatment may continue indefinitely.

FDA-Approved Buprenorphine Products For The Treatment Of Opioid Dependence Include:

  • Bunavail (buprenorphine and naloxone) buccal film
  • Cassipa (buprenorphine and naloxone) sublingual film
  • Probuphine (buprenorphine) implant for subdermal administration
  • Sublocade (buprenorphine extended‐release) injection for subcutaneous use
  • Suboxone (buprenorphine and naloxone) sublingual film for sublingual or buccal use, or sublingual tablet.
  • Subutex (buprenorphine) sublingual tablet
  • Zubsolv (buprenorphine and naloxone) sublingual tablets

FDA-Approved Methadone Products For The Treatment Of Opioid Dependence Include:

  • Dolophine (methadone hydrochloride) tablets
  • Methadose (methadone hydrochloride) oral concentrate

FDA-Approved Naltrexone Products For The Treatment Of Opioid Dependence Include:

  • Vivitrol (naltrexone for extended-release injectable suspension) intramuscular

What Are The Goals Of Medication-Assisted Treatment?

The goal of medication-assisted treatments is to control a specific set of conditions during the early stages of recovery. Once the conditions are addressed, the individual should taper off the medication as they replace negative coping skills with functional behaviors.


There are three primary medications approved by the FDA for MAT:


Buprenorphine: Reduces cravings and eases withdrawal symptoms.
Methadone: Also cuts cravings and eases withdrawal but is usually dispensed in specialized clinics.
Naltrexone: Blocks the high from opioids and is often administered as a monthly shot.

Several formulations of these medications are also available, such as buccal films, sublingual tablets, and extended-release injections.

Yes, MAT treatment plans are tailored to each individual’s needs. All three FDA-approved medications should be made available to patients so that the most appropriate treatment option can be selected. The duration of treatment varies from person to person, and there’s no maximum recommended duration for maintenance treatment.

MAT can be a long-term solution for some individuals, especially given the chronic nature of OUD. The need for continuing MAT should be re-evaluated periodically, and for some patients, treatment may continue indefinitely.

Yes, MAT is available in California, including specialized addiction treatment centers and some general healthcare settings. If you’re looking for addiction treatment in California that includes MAT, contact our team at California Prime Today to start your journey.

Consult with our team of professionals at California Prime Recovery for a full evaluation to determine if MAT is the appropriate treatment option. Factors such as the severity of the opioid dependence, any existing co-occurring disorders, and patient preferences will all be considered.

Yes, MAT is considered safe and effective when used in combination with counseling and psychosocial support. However, like any medical treatment, it’s crucial to consult with healthcare providers for a personalized treatment plan.

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