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Understanding Prednisone: Uses, Side Effects, and Risks

Clinically Reviewed by: Charee Marquez, LMFT

Prednisone, an oral corticosteroid, finds widespread use in the medical field for its versatile applications in treating various conditions characterized by inflammation and immune system dysfunction. Understanding prednisone’s uses is paramount for patients and healthcare professionals alike, as it can effectively manage inflammatory bowel disease, allergies, asthma, and other health problems. However, alongside its therapeutic benefits, prednisone comes with potential risks and adverse effects that require careful consideration. These may include elevated blood pressure, weight gain, high blood sugar levels, and increased susceptibility to infections. Informed choices regarding prednisone usage are essential for mitigating these risks and optimizing its benefits in promoting health and well-being.

Patients should inform their healthcare provider about all medications they are taking, including birth control pills, to avoid potential drug interactions.

What Is Prednisone?

Prednisone is a synthetic corticosteroid medication that belongs to a class of drugs known as glucocorticoids or corticosteroids. It is commonly used for its anti-inflammatory and immunosuppressive properties. Prednisone is a prescription medication that is available in various forms, including oral tablets, oral solutions, and oral delayed-release tablets.

Prednisone Types and Dosages

Prednisone is typically prescribed in oral form, and dosage can vary based on the severity of the condition and individual patient factors.


  1. Oral Tablets:

    • Prednisone is commonly available in oral tablet form. Tablets come in various strengths, such as 1 mg, 5 mg, 10 mg, 20 mg, and 50 mg.
  2. Oral Solution:

    • A liquid form of prednisone is available as an oral solution, which can be particularly useful for individuals who may have difficulty swallowing tablets.
  3. Delayed-Release Tablets:

    • Some formulations of prednisone are designed as delayed-release tablets, which release the medication in a controlled manner to reduce the risk of gastrointestinal irritation.


Prednisone dosages are highly individualized, and the specific dose prescribed will depend on factors such as the medical condition being treated, the severity of symptoms, the patient’s age, weight, and overall health. Dosages are often initiated at a higher level and then tapered down gradually to the lowest effective dose.

Common dosages for various conditions include:

  1. Anti-Inflammatory/Immunosuppressive Dosages:

    • Initial dose: 5 mg to 60 mg per day, depending on the condition.
    • Maintenance dose: Adjusted based on response and symptoms.
  2. Asthma Exacerbation:

    • Higher doses may be prescribed during acute exacerbations, typically starting at 40 mg to 60 mg per day and tapering down.
  3. Rheumatoid Arthritis:

    • Initial dose: 5 mg to 10 mg per day.
    • Maintenance dose: Adjusted based on disease activity.
  4. Autoimmune Disorders:

    • Dosages can vary widely, and treatment is typically individualized.
  5. Allergic Reactions:

    • Higher doses may be used initially, followed by a tapering schedule.

It’s important to note that prednisone should be taken exactly as prescribed by a healthcare professional. Abruptly stopping the medication or changing the dosage without medical guidance can lead to potential side effects and complications.

Prednisone Dosage Guidelines

Dosage guidelines for prednisone can vary depending on the medical condition being treated, the severity of symptoms, and individual patient factors such as age, weight, and overall health. Prednisone is a corticosteroid medication that is commonly used to treat a wide range of inflammatory and autoimmune conditions. Here are some general dosage guidelines for prednisone:

  1. Inflammatory Conditions:

    • Starting dose: The initial dose of prednisone for inflammatory conditions typically ranges from 5 to 60 milligrams (mg) per day, depending on the severity of symptoms and the specific condition being treated.
    • Maintenance dose: Once symptoms are controlled, the dosage of prednisone is often tapered gradually to the lowest effective dose to maintain symptom relief while minimizing the risk of side effects.
    • Dosage adjustments: Healthcare providers may adjust the dosage of prednisone based on individual response to treatment, with higher doses required for more severe symptoms or flare-ups.
  2. Autoimmune Disorders (e.g., rheumatoid arthritis, lupus):

    • Starting dose: The initial dose of prednisone for autoimmune disorders typically ranges from 5 to 60 mg per day, depending on disease activity and severity.
    • Maintenance dose: Once disease activity is under control, the dosage of prednisone is often tapered gradually to the lowest effective dose to prevent disease flares while minimizing side effects.
  3. Allergic Reactions (e.g., asthma exacerbations, allergic dermatitis):

    • Acute exacerbations: Prednisone may be prescribed at higher doses (e.g., 40-60 mg per day) for short-term use during acute allergic reactions or asthma exacerbations.
    • Maintenance therapy: For chronic allergic conditions, prednisone may be prescribed at lower doses (e.g., 5-20 mg per day) for longer-term maintenance therapy.
  4. Other Conditions:

    • Dosage and duration of prednisone treatment may vary for other conditions, such as organ transplant rejection, certain types of cancer, and adrenal insufficiency. Healthcare providers will determine the appropriate dosage and treatment duration based on individual patient needs and response to treatment.

It’s important to take prednisone exactly as prescribed by a healthcare provider and to follow any dosage adjustments or tapering schedules provided. Abruptly stopping prednisone can lead to withdrawal symptoms or a rebound of symptoms, so any changes to the dosage should be made under medical supervision. If you have any questions or concerns about prednisone dosage, be sure to consult with a healthcare provider for personalized advice.

Common Prednisone Variations

  1. Generic Prednisone:

    • This is the standard form of the medication and is available in various strengths, typically ranging from 1 mg to 50 mg. Generic prednisone is widely prescribed and is often used to treat a variety of inflammatory conditions.
  2. Deltasone:

    • Deltasone is a brand name for prednisone. It is essentially the same medication but is marketed under the brand name Deltasone. It is available in oral tablet form, and the dosage may vary.
  3. Rayos:

    • Rayos is a delayed-release formulation of prednisone. It is designed to release the medication in a way that can help minimize the side effects associated with immediate-release formulations. Rayos is used for certain conditions where timing of the medication release is important.
  4. Prednisone Intensol:

    • Prednisone Intensol is an oral solution of prednisone, often used when individuals have difficulty swallowing tablets. It provides a liquid form of the medication for easier administration.

Prednisone Uses for the Immune System

Here are some common uses of prednisone:

  1. Inflammatory Conditions:

  • Rheumatoid Arthritis: Prednisone may be prescribed to reduce inflammation and manage symptoms in individuals with rheumatoid arthritis.

  • Systemic Lupus Erythematosus (SLE): It can be used to control inflammation in patients with systemic lupus erythematosus.

  • Inflammatory Bowel Disease (IBD): Prednisone may be used during flare-ups of conditions like Crohn’s disease or ulcerative colitis to reduce inflammation.

  • Body Aches: Prednisone can be used to relieve body aches associated with inflammation.

  1. Allergic Reactions:

  • Prednisone can be used to treat severe allergic reactions, including anaphylaxis.

  • It may be prescribed to manage allergic conditions like asthma and hay fever.

  1. Skin Conditions:

  • Dermatitis and Eczema: Prednisone may be prescribed for short-term use to relieve inflammation and itching associated with dermatitis and eczema.

  • Psoriasis: It can be used to control inflammation and reduce symptoms in psoriasis.

  1. Respiratory Conditions:

  • Asthma: Prednisone may be prescribed during acute exacerbations of asthma to reduce inflammation in the airways.

  • Chronic Obstructive Pulmonary Disease (COPD): It can be used in certain situations to manage exacerbations and reduce inflammation.

  1. Autoimmune Disorders:

  • Prednisone is often used in the treatment of various autoimmune disorders, including lupus, myasthenia gravis, and vasculitis.

  1. Organ Transplants:

  • In organ transplant recipients, prednisone is used as part of immunosuppressive regimens to prevent organ rejection.

  1. Cancer Treatment:

  • Prednisone may be used as part of cancer treatment protocols, especially for lymphomas and certain leukemias.

  1. Nerve and Muscular Disorders:

  • Multiple Sclerosis (MS): Prednisone may be used to manage acute exacerbations in individuals with multiple sclerosis.

  • Myasthenia Gravis: It can be part of the treatment plan for myasthenia gravis.

  1. Hematologic Disorders:

  • Prednisone may be used in certain hematologic disorders, such as autoimmune hemolytic anemia and thrombocytopenia.

How Long Does Prednisone Stay in Your System?

The half-life of prednisone, a corticosteroid medication, is relatively short. The half-life is the time it takes for half of the drug to be eliminated from the body. For prednisone, the half-life is approximately 2 to 4 hours. This means that after this time period, approximately half of the prednisone dose would be metabolized and eliminated from the body.

It’s important to note that prednisone is a prodrug, meaning it is metabolized in the liver to its active form, prednisolone, which has a longer half-life. Prednisolone is the active compound responsible for the anti-inflammatory and immunosuppressive effects associated with prednisone use.

While the half-life gives an indication of how long it takes for the drug to be eliminated, the duration of action of prednisone is influenced by various factors, including the specific condition being treated, the dosage, and the individual’s metabolism. In some cases, especially when using higher doses or for long-term therapy, the effects of prednisone can last beyond its elimination half-life.

Prednisone Onset and Duration

The onset and duration of action of prednisone, a corticosteroid medication, can vary depending on the specific condition being treated, the dosage, and individual factors. Here’s a general overview:

Onset of Action:

  1. Oral Administration:

    • Prednisone is typically administered orally, and its onset of action is relatively rapid. Some effects may be noticeable within a few hours, especially in terms of anti-inflammatory and immunosuppressive actions.
  2. Short-Term Use:

    • For short-term use in acute conditions, individuals may experience symptom relief relatively quickly, often within hours to a day.
  3. Long-Term Use:

    • In cases of chronic conditions or when used for long-term therapy, it may take several days to weeks to see the full therapeutic effects. The onset of action can be more gradual in these situations.

Duration of Action:

  1. Short-Term Use:

    • The effects of a single dose of prednisone can last for a variable duration, but typically, the medication is administered once or twice daily. For short-term courses, the effects may last for the duration of the dosing interval.
  2. Long-Term Use:

    • When used for chronic conditions, the duration of action is influenced by factors such as the dosage, the specific condition being treated, and individual responses. It’s important to note that the full benefits of prednisone in chronic conditions may take some time to manifest.
  3. Tapering:

    • In long-term or high-dose scenarios, a healthcare provider may prescribe a tapering schedule when discontinuing prednisone. This helps minimize the risk of withdrawal symptoms and allows the body to adjust gradually.

It’s essential for individuals taking prednisone to follow their healthcare provider’s prescribed dosage and schedule. Abruptly stopping prednisone, especially after prolonged use, can lead to withdrawal symptoms and potential complications.

Prednisone Efficacy

The efficacy of prednisone, a corticosteroid medication, is well-established for the treatment of various inflammatory and immune-mediated conditions. The drug’s effectiveness is attributed to its potent anti-inflammatory and immunosuppressive properties. Prednisone is widely used in the medical field for managing a range of conditions, and its efficacy is observed across different therapeutic areas. Here are some key areas where prednisone has demonstrated efficacy:

  1. Inflammatory and Autoimmune Conditions:

    • Rheumatoid Arthritis: Prednisone is used to reduce inflammation and manage symptoms in individuals with rheumatoid arthritis.
    • Lupus (Systemic Lupus Erythematosus): It is employed to control inflammation in patients with lupus.
    • Inflammatory Bowel Disease (Crohn’s Disease, Ulcerative Colitis): Prednisone can be used during flare-ups to reduce inflammation in the gastrointestinal tract.
    • Dermatological Conditions (Eczema, Psoriasis): Prednisone may provide relief from inflammation and itching associated with various skin conditions.
  2. Respiratory Conditions:

    • Asthma: Prednisone is often used during acute exacerbations to reduce airway inflammation and manage symptoms.
    • Chronic Obstructive Pulmonary Disease (COPD): It may be employed in certain situations to address exacerbations and reduce inflammation.
  3. Allergic Reactions:

    • Prednisone is used to manage severe allergic reactions and anaphylaxis.
  4. Organ Transplants:

    • Prednisone is part of immunosuppressive regimens to prevent organ rejection following transplantation.
  5. Hematological Disorders:

    • It may be used in autoimmune hemolytic anemia and certain thrombocytopenias.
  6. Nervous System Disorders:

    • Multiple Sclerosis (MS): Prednisone can be used to manage acute exacerbations in individuals with MS.
  7. Cancer Treatment:

    • It may be used as part of cancer treatment protocols, especially in lymphomas and leukemias.
  8. Adrenal Insufficiency:

    • Prednisone is used to replace deficient cortisol in individuals with adrenal insufficiency.

The efficacy of prednisone is often dependent on factors such as the specific condition being treated, the dosage, and the individual patient’s response. While prednisone can provide rapid relief of symptoms, especially in acute situations, it is often used cautiously due to potential side effects associated with long-term use.

Prednisone Storage and Disposal


  • Store prednisone in a cool, dry place, away from direct sunlight and moisture.
  • Keep it out of reach of children and pets.
  • Check the expiration date regularly, and do not use if it has expired.


  • Do not flush prednisone down the toilet.
  • Avoid throwing it in the household trash unless specified.
  • Use local medication take-back programs or events.
  • Consider using medication disposal bags or mix tablets with unappealing substances before disposal.
  • Remove personal information from packaging.
  • Consult with your pharmacist or healthcare provider for guidance on proper disposal.

Precautions of Prednisone

Before taking prednisone, it’s important to consider several precautions to ensure its safe and effective use:

  1. Medical History: Inform your healthcare provider about your complete medical history, including any past or present health conditions, allergies, and medications you are currently taking. Prednisone may interact with certain medications or exacerbate certain health conditions.

  2. Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of prednisone with your doctor. Prednisone may pose risks to the fetus or nursing infant and should only be used if the potential benefits outweigh the potential risks.

  3. Allergies: Inform your healthcare provider about any allergies you have, especially if you are allergic to prednisone or any other corticosteroids. Prednisone tablets may contain inactive ingredients that can cause allergic reactions or other problems.

  4. Infections: Prednisone can suppress the immune system, increasing the risk of infections. Inform your doctor if you have any current infections or have been recently exposed to someone with an infectious illness. Avoid close contact with individuals who have contagious illnesses, and seek medical attention if you develop any signs of infection while taking prednisone.

  5. Blood Pressure and Blood Sugar Levels: Prednisone may cause increases in blood pressure and blood sugar levels. If you have high blood pressure, diabetes, or other cardiovascular or metabolic conditions, your doctor may monitor these parameters more closely while you are taking prednisone.

  6. Bone Health: Long-term use of prednisone may increase the risk of osteoporosis and bone fractures. Your doctor may recommend calcium and vitamin D supplements or other medications to help protect your bone health while taking prednisone.

  7. Eye Health: Prednisone may increase the risk of developing glaucoma or cataracts. If you have a history of eye problems, inform your healthcare provider before starting prednisone, and undergo regular eye examinations while taking the medication.

  8. Mental Health: Prednisone may cause mood changes, anxiety, depression, or other psychiatric symptoms. Inform your doctor if you have a history of mental health disorders or if you experience any changes in mood or behavior while taking prednisone.

  9. Dosage and Duration: Take prednisone exactly as prescribed by your healthcare provider. Do not increase or decrease your dose without consulting your doctor. Prednisone should be tapered off gradually to prevent withdrawal symptoms if you have been taking it for an extended period.

  10. Side Effects: Be aware of potential side effects of prednisone, including nausea, vomiting, dizziness, fatigue, weight gain, and fluid retention. If you experience any concerning symptoms, contact your doctor promptly.

By following these precautions and closely monitoring your health while taking prednisone, you can minimize the risks and maximize the benefits of this medication. Always consult your healthcare provider if you have any questions or concerns about taking prednisone.

Adverse Effects and Risks of Prednisone

Prednisone, a corticosteroid medication, is associated with a range of side effects, both short-term and long-term. The severity and likelihood of side effects can vary depending on factors such as the dosage, duration of use, and individual patient characteristics. Here are common short-term and long-term side effects associated with prednisone:

Short-Term Side Effects:

  • Increased appetite

  • Weight gain

  • Insomnia

  • Mood swings

  • Gastrointestinal Distress

  • Sore throat

Long-Term Side Effects:

  • Osteoporosis

  • Hypertension

  • Diabetes

  • Increased risk of infections

  • Cataracts

  • Muscle weakness

Short-Term Side Effects:

  1. Increased Appetite:

    • Short-term use of prednisone can lead to an increased appetite, potentially resulting in weight gain.

  2. Fluid Retention:

    • Prednisone may cause fluid retention, leading to bloating and swelling, especially in the extremities.

  3. Mood Changes:

    • Some individuals may experience mood swings, irritability, or changes in mood during short-term use.

  4. Insomnia:

    • Difficulty sleeping or insomnia can occur as a short-term side effect.

  5. Gastrointestinal Distress:

    • Prednisone may cause stomach upset, indigestion, or nausea in some individuals.

  6. Increased Blood Sugar:

    • Short-term use can elevate blood sugar levels, which may be a concern for individuals with diabetes.

  7. Increased Risk of Infections:

    • Prednisone can suppress the immune system, increasing the risk of infections during short-term use.

  8. Increased Blood Pressure:

    • Blood pressure may rise temporarily during short-term use.

Long-Term Side Effects: Weight Gain

  1. Osteoporosis:

    • Prolonged use of prednisone can lead to bone loss and an increased risk of osteoporosis.

  2. Cataracts and Glaucoma:

    • Long-term use may contribute to the development of cataracts and an increased risk of glaucoma.

  3. Adrenal Suppression:

    • Chronic use can suppress the natural production of cortisol by the adrenal glands, leading to adrenal insufficiency.

  4. Skin Changes:

    • Long-term use may cause thinning of the skin, easy bruising, and increased susceptibility to skin infections.

  5. Muscle Weakness:

    • Chronic use may result in muscle weakness and atrophy.

  6. Gastrointestinal Issues:

    • Long-term use may increase the risk of stomach ulcers and gastrointestinal bleeding.

  7. Metabolic Effects:

    • Prolonged use can lead to metabolic changes, such as increased fat deposits in the abdomen (central obesity).

  8. Increased Risk of Cardiovascular Events:

    • Some studies suggest an increased risk of cardiovascular events with long-term corticosteroid use.

  9. Suppression of Growth in Children:

    • Long-term use in children may lead to growth suppression.

Prednisone and Pregnancy

The use of prednisone during pregnancy should be carefully considered, and decisions regarding its use should be made in consultation with a healthcare professional. Prednisone is a corticosteroid, and its safety during pregnancy depends on several factors, including the specific medical condition being treated, the dosage, and the duration of use.

Prednisone, Alcohol Use, and High Blood Pressure

The combination of prednisone and alcohol can pose risks and may not be recommended for everyone. Both prednisone and alcohol can have significant effects on the body, and their interaction can potentially exacerbate certain side effects or health concerns. Here are some important considerations regarding prednisone and alcohol use:

  1. Gastrointestinal Effects: Both prednisone and alcohol can irritate the lining of the stomach and increase the risk of gastrointestinal side effects such as stomach ulcers, gastritis, and gastrointestinal bleeding. Combining the two may further increase the likelihood of these adverse effects.

  2. Weakening of the Immune System: Prednisone suppresses the immune system, which can increase susceptibility to infections. Alcohol consumption can also impair immune function, potentially heightening the risk of infections or delaying recovery from illnesses while taking prednisone.

  3. Liver Function: Prednisone is metabolized in the liver, and chronic alcohol consumption can also have adverse effects on liver function. Combining prednisone with alcohol may increase the risk of liver damage or exacerbate existing liver conditions.

  4. Central Nervous System Effects: Both prednisone and alcohol can affect mood, cognition, and behavior. Combining the two may increase the risk of central nervous system side effects such as mood swings, irritability, depression, or impaired judgment.

  5. Fluid Retention and Blood Pressure: Prednisone can cause fluid retention and increase blood pressure, while alcohol consumption can further exacerbate these effects. Combining prednisone with alcohol may increase the risk of fluid retention, hypertension, and cardiovascular complications.

  6. Interference with Medication Absorption: Alcohol can interfere with the absorption and metabolism of medications, potentially reducing the effectiveness of prednisone or altering its pharmacokinetics. It’s important to follow healthcare provider recommendations regarding the timing and administration of prednisone in relation to alcohol consumption.

Can You Overdose on Prednisone?

Yes, it is possible to overdose on prednisone, although it is relatively rare. Prednisone is a corticosteroid medication that can have significant effects on the body, particularly when taken in large doses or for an extended period. An overdose of prednisone can lead to serious health complications and may require medical attention.

Misuse of Prednisone

Misuse of prednisone, a prescription corticosteroid medication, can occur for various reasons, often driven by misunderstandings about its effects or a desire to self-medicate. Misuse of prednisone can lead to severe mental health issues, including failed suicide attempts. Here are some potential reasons why individuals may misuse prednisone:

  1. Inadequate Understanding of the Medication: Some individuals may misuse prednisone due to a lack of understanding about its proper use and potential side effects. They may self-prescribe or take prednisone without a healthcare provider’s guidance, believing it will help alleviate symptoms without considering the risks.

  2. Desire to Control Symptoms: Prednisone is known for its potent anti-inflammatory effects, making it tempting for individuals to misuse it in an attempt to control symptoms such as pain, swelling, or inflammation. However, using prednisone without medical supervision can lead to improper dosing and potentially harmful side effects.

  3. Treatment of Non-Indicated Conditions: Some individuals may misuse prednisone to treat conditions for which it is not indicated or approved, such as mild allergies, colds, or minor aches and pains. Using prednisone inappropriately for these purposes can expose individuals to unnecessary risks and side effects.

  4. Weight Management: Prednisone can cause temporary weight gain and increased appetite as side effects. Some individuals may misuse prednisone in an attempt to suppress appetite or promote weight loss, unaware of the potential risks and adverse effects associated with its use.

  5. Performance Enhancement: In rare cases, athletes or individuals seeking to enhance physical performance may misuse prednisone to reduce inflammation or mask pain associated with injuries. However, using prednisone in this manner is not only ineffective but can also lead to serious health complications.

Signs of Prednisone Misuse

  1. Taking Prednisone Without a Prescription: Individuals who obtain prednisone without a valid prescription or through illicit means may be misusing the medication.

  2. Excessive or Inappropriate Use: Misuse of prednisone may involve taking higher doses than prescribed, taking it more frequently than recommended, or using it for longer durations than necessary.

  3. Self-Medication: People who self-diagnose conditions and self-medicate with prednisone without consulting a healthcare provider may be misusing the medication.

  4. Ignoring Healthcare Provider’s Advice: Individuals who disregard their healthcare provider’s advice regarding prednisone use, dosage adjustments, or tapering schedules may be at risk of misuse.

  5. Unexpected Side Effects: Experiencing unexpected or severe side effects of prednisone use, such as mood changes, gastrointestinal problems, or changes in weight, may indicate misuse or improper use of the medication.

If you suspect that someone is misusing prednisone or if you are concerned about your own use of the medication, it’s essential to seek guidance from a healthcare provider. They can provide education, support, and appropriate treatment to address underlying issues and ensure safe and effective medication use.


In conclusion, prednisone stands as a cornerstone in the treatment arsenal for a wide range of diseases and health conditions, offering significant benefits in managing inflammation and immune system disorders. However, its usage necessitates a thorough understanding of its potential adverse effects and risks, including hypertension, hyperglycemia, and osteoporosis. Patients and healthcare providers must collaborate closely to assess the benefits and risks of prednisone therapy, tailoring treatment plans to individual needs and monitoring for any signs of complications or adverse reactions. By fostering informed choices and vigilant management, prednisone can continue to play a valuable role in improving patient outcomes and enhancing quality of life.

The movie ‘Side Effects’, directed by Steven Soderbergh, portrays the character Emily Taylor’s struggles with medication misuse, highlighting the importance of proper medical supervision.

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Prednisone is prescribed for various medical conditions, including inflammatory disorders, autoimmune diseases, and allergies. It helps reduce inflammation and suppress an overactive immune system.

Yes, prolonged misuse of Prednisone can lead to dependence and addiction, making it crucial to use it only as prescribed by a healthcare provider.

Signs of Prednisone abuse may include taking the medication without a valid prescription, seeking multiple prescriptions from different doctors, or displaying signs of addiction.

If you suspect Prednisone abuse in yourself or someone you know, it is essential to seek professional help promptly. Reach out to a healthcare provider or a rehabilitation center for assistance.

California Prime Recovery offers comprehensive support and treatment for individuals struggling with substance abuse, including Prednisone. Contact us at 866-208-2390 to learn more about our services and how we can help.

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