Author & Editor: Adam Tomlinson
Clinically Reviewed by: Charee Marquez, LMFT
Clinical Contributor: Karynne Witkin, M.A. I/O Psychology
Understanding Toradol Side Effects: Short & Long-Term
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Toradol (ketorolac) is a strong nonsteroidal anti-inflammatory drug (NSAID) used for short-term relief of moderately severe pain, often after surgery or injury. Toradol belongs to a class of anti inflammatory drugs NSAIDs, which are used to reduce pain, inflammation, and fever. Medications called NSAIDs, such as ketorolac, are commonly prescribed for acute pain following injury, illness, or surgery. It is especially effective for acute pain. Available as an oral tablet or injection, it is effective but carries important safety considerations that limit how long it can be used.
Understanding toradol side effects is essential, as this medication can affect the stomach, heart, kidneys, liver, and overall health—sometimes in ways that are not immediately obvious. Certain medical conditions and drug interactions can increase these risks.
Continue reading to learn what to watch for, who may be at higher risk, and how Toradol should be used safely.
What is Toradol?
Toradol, also known by its generic name ketorolac, is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve moderate to severe pain. It is often prescribed for short-term use, especially after surgeries or injuries, due to its strong pain-relieving effects. Unlike opioids, Toradol does not cause sedation or addiction, making it a popular option for doctors. Compared to NSAIDs such as ibuprofen, Toradol is generally used for more severe pain and has a higher risk profile, so understanding the differences in side effects and risks between these medications is important. While Toradol is effective for pain control, it carries a higher gastrointestinal risk and may not be suitable for patients with cardiovascular disease or those at increased risk for these conditions. However, it also carries a risk of side effects, especially when used for more than a few days. Understanding the dosage limits and potential serious side effects of nonsteroidal anti-inflammatory drugs, such as an increased risk of heart attack, stroke, gastrointestinal, and kidney complications, is important for safe use.
Common Toradol Side Effects You Should Know
Toradol is a powerful pain reliever, but it can cause side effects that users should watch for. The most common Toradol side effects include nausea, dizziness, headache, and upset stomach. Some patients may experience both abdominal pain and nausea together, sometimes referred to as pain nausea, during treatment. Some people may also experience drowsiness or diarrhea. These symptoms are usually mild and go away as the body adjusts to the medication. Nasal discomfort, such as nasal irritation or rhinitis, is a common adverse event, especially when using the nasal spray form. However, in some cases, side effects may be more intense or last longer. Taking Toradol with food or a full glass of water may help reduce stomach-related issues. Always follow your doctor’s instructions and report any side effects that become bothersome.
What Is Ketorolac Used For? Understanding This Nonsteroidal Anti Inflammatory Drug
Ketorolac is used to treat moderate to severe pain, usually for a short period. Doctors often prescribe it after surgeries, injuries, or medical procedures, including dental surgery. It works by blocking the body’s production of substances that cause pain and inflammation. Ketorolac is not meant for long-term use and is typically given for no more than 5 days. It is available as an injection, oral tablet, or nasal spray. Ketorolac nasal spray is another formulation, used in certain clinical settings and associated with specific side effects such as nasal discomfort and increased risk of bleeding. Unlike opioids, ketorolac does not cause dependence, making it a non-addictive option for pain relief in many clinical settings.
How Does Toradol Work? – Key Points
Blocks COX-1 and COX-2 enzymes
Reduces prostaglandin production
Lowers pain, inflammation, and fever
Provides fast, short-term relief
Commonly used after surgery or injury
Does not treat the cause, only symptoms
Typically prescribed for 5 days or less
Available in injection and tablet forms
Toradol Imprints and Dosage
Common Toradol Tablet Imprints:
TORADOL 10 – Yellow, round tablet with “TORADOL” and “10” imprint
Ketorolac 10 mg (Generic) – May vary by manufacturer but often imprinted with “93” and “314” or similar codes
Typical Dosage Guidelines:
Oral Dose: 10 mg every 4 to 6 hours as needed
Maximum Daily Dose (Oral): 40 mg per day
Injection (IM or IV): 15 mg to 30 mg every 6 hours as needed
Maximum Duration: Use limited to 5 days total, regardless of form
Important Notes:
Not for long-term use due to risk of serious side effects
Dosage may be adjusted for age, weight, kidney function, or health condition
Always follow prescribing doctor’s instructions exactly
How to Safely Store and Dispose of Toradol
Storage Tips:
Keep Toradol at room temperature (68°F to 77°F or 20°C to 25°C)
Store in a dry place, away from moisture and direct light
Keep it in the original container with the lid tightly closed
Do not store in the bathroom or near heat sources
Keep out of reach of children and pets
Disposal Guidelines:
Do not flush Toradol down the toilet or pour it down the drain
Use a local drug take-back program if available
If no program is available, mix unused Toradol with an unappealing substance like coffee grounds or cat litter
Place the mixture in a sealed plastic bag and throw it in the household trash
Remove personal information from the prescription label before disposal
Is Ketorolac Addictive?
No, ketorolac is not addictive. It is a nonsteroidal anti-inflammatory drug (NSAID), not an opioid. It does not produce feelings of euphoria or cravings linked to addiction. Because of this, ketorolac is often used as a safer alternative to opioids for short-term pain relief. However, misuse or long-term use can still lead to serious health risks, such as kidney damage or stomach bleeding. Always use ketorolac exactly as prescribed and for no more than 5 days to reduce the risk of side effects.
Toradol Effects and Risks: Short and Long Term
Short-Term Effects:
Pain relief
Reduced inflammation
Nausea
Dizziness
Headache
Drowsiness
Upset stomach
Diarrhea
Short-Term Risks:
Allergic reaction (rash, swelling, breathing problems)
Stomach irritation or bleeding
Increased blood pressure
Fluid retention
Severe skin reaction (Exfoliative Dermatitis, Stevens-Johnson Syndrome, Toxic Epidermal Necrolysis)
Long-Term Risks (if used beyond 5 days or repeatedly):
Stomach ulcers or serious gastrointestinal bleeding
Kidney damage or failure
Acute renal failure
Liver issues
Increased risk of heart attack or stroke
Delayed healing in surgical patients
Toradol is effective for short-term pain but should not be used long term due to serious health risks. NSAIDs like Toradol can cause acute renal failure, especially in patients who are volume-depleted, have pre-existing kidney issues, or are taking other nephrotoxic drugs. Always follow your healthcare provider’s instructions.
Toradol Side Effects vs. Other NSAIDs: A Comparison
Toradol has stronger pain relief than most NSAIDs but also carries higher risk. Compared to ibuprofen or naproxen, Toradol is more likely to cause stomach bleeding, kidney strain, and serious side effects if used for more than 5 days. While typical NSAIDs are often used long term, Toradol is for short-term use only due to its increased risk profile. Always use under medical supervision.
How Long Do Toradol Side Effects Last?
Most Toradol side effects are short-term and go away within a few hours to a couple of days after the last dose. Common symptoms like nausea, headache, or dizziness usually fade quickly as the drug leaves the body. More serious side effects, such as stomach bleeding or kidney problems, may last longer and require medical treatment. Since Toradol is typically used for no more than 5 days, side effects are usually limited to that period.
High-risk groups include:
Patients with active peptic ulcer disease (Toradol is contraindicated in these individuals)
Patients with a history of peptic ulcer disease (increased risk of GI complications)
Individuals with aspirin sensitive asthma (Toradol should be avoided due to risk of allergic reactions)
Patients with advanced renal impairment (Toradol is contraindicated in this group)
Patients with any degree of renal impairment (dose adjustments or avoidance may be necessary)
Pediatric patients (safety and risks are different in children; Toradol is generally not recommended except in specific circumstances)
Patients with a history of stomach ulcers or bleeding
People with kidney disease
Elderly patients
Patients scheduled for major surgery (such as knee or hip replacement, hysterectomy, or other extensive operations) should not use Toradol due to increased risk of bleeding and complications.
Always contact your doctor if symptoms continue or get worse, or call your doctor for further guidance.
Who Should Avoid Toradol? High-Risk Groups Explained, Including Those with High Blood Pressure
Toradol is not safe for everyone. Certain groups face a higher risk of serious side effects and should avoid using it.
High-Risk Groups Include:
People with Kidney Disease – Toradol can worsen kidney function
Those with Active Ulcers or GI Bleeding – Increases risk of stomach or intestinal bleeding
Patients with Heart Disease or Stroke History – May raise blood pressure and heart attack risk
Elderly Adults – Higher chance of kidney and stomach issues
Pregnant Women in Late Pregnancy – Can harm the baby or cause delivery problems
People Taking Blood Thinners – Risk of bleeding increases
Anyone Allergic to NSAIDs or Aspirin – Can trigger dangerous reactions
People with nasal polyps or a history of severe allergic reactions to NSAIDs – Increased risk of allergic or respiratory complications
Always tell your doctor about your full medical history before using Toradol.
Managing Toradol Side Effects: What You Can Do
Take with food or water to reduce stomach upset
Stay hydrated to support kidney function
Avoid alcohol to lower risk of bleeding
Report symptoms like severe pain, rash, or breathing issues
Use only as prescribed and never exceed 5 days
Monitor blood pressure if you have heart concerns
Tell your doctor about all medications you’re taking
Talk to your doctor if you have any concerns about side effects or medication interactions
Following these steps can help reduce side effects and improve safety while using Toradol.
Can Toradol Cause Kidney Damage or Stomach Bleeding? What Studies Reveal
Yes, studies show that Toradol can cause kidney damage, especially with high doses or use longer than 5 days. It reduces blood flow to the kidneys, which may lead to reduced kidney function or failure, particularly in older adults or those with preexisting kidney issues. Doctors closely monitor kidney health when prescribing Toradol. Patients taking angiotensin converting enzyme inhibitors should be monitored closely, as the combination with Toradol increases the risk of kidney problems.
Toradol Side Effects in Elderly Patients: Special Considerations
Elderly patients face a higher risk of serious Toradol side effects. These include stomach bleeding, kidney damage, and increased blood pressure. Age-related changes in kidney function can make it harder for the body to process the drug, raising the chance of harmful buildup. Doctors often prescribe lower doses and monitor closely. Toradol should be used with caution in patients over 65 and only for short-term pain relief. Unusual behavior, muscle cramps, hoarseness, dark urine, and unusual weight gain may signal a serious decrease in organ function, fluid retention, or other serious side effects and should be reported to a doctor immediately.
Allergic Reactions to Toradol: Symptoms and What to Do
Allergic reactions to Toradol are rare but can be serious, including severe allergic reactions that may be life-threatening, as well as severe skin reactions such as Exfoliative Dermatitis, Stevens-Johnson Syndrome (SJS), and Toxic Epidermal Necrolysis (TEN). Symptoms may include rash, itching, swelling (especially of the face, tongue, or throat), dizziness, and trouble breathing. These signs usually appear shortly after taking the medication. If you notice any of these symptoms, stop using Toradol immediately and seek emergency medical help. Do not take Toradol again if you’ve had an allergic reaction in the past. Always inform your doctor about any known drug allergies before starting treatment.
What Happens if You Take Too Much Toradol?
Taking too much Toradol can lead to serious health problems. Symptoms of overdose may include severe stomach pain, severe vomiting, vomiting, drowsiness, shallow breathing, kidney failure, and even coma. An overdose increases the risk of internal bleeding and long-term organ damage. If you suspect an overdose, seek emergency medical help right away. Never take more than the prescribed dose, and do not use Toradol for longer than 5 days to reduce the risk of overdose.
Toradol and Alcohol: Why You Shouldn’t Mix Them
Mixing Toradol with alcohol increases the risk of serious side effects. Both can irritate the stomach lining, raising the chance of ulcers and internal bleeding. This combination also puts extra stress on the kidneys and liver, which can lead to long-term damage. Even small amounts of alcohol can make Toradol side effects worse, such as dizziness, nausea, or stomach pain. There is also a risk of cardiovascular thrombotic events, such as heart attack or stroke, particularly in patients with pre-existing risk factors. To stay safe, avoid alcohol completely while taking Toradol.
Toradol Use After Surgery: Benefits and Side Effects
Benefits: Toradol is often used after surgery to relieve moderate to severe pain. The first dose is often given by injection in a hospital or medical office so that patients can be properly monitored. It works quickly and helps reduce the need for opioids, which lowers the risk of addiction and drowsiness. It also helps control inflammation and swelling at the surgical site.
Side Effects: Common side effects include nausea, dizziness, and stomach pain. More serious risks include bleeding, kidney problems, and delayed wound healing. Ketorolac should not be used when bleeding risk is elevated or when hemostasis is incomplete, due to its effects on platelet function. Because of these risks, Toradol is usually given for no more than 5 days after surgery and under close medical supervision.
Toradol Precautions
Use only as prescribed and for no more than 5 days
Stop taking oral ketorolac after 5 days or as directed by your healthcare provider
Avoid if pregnant in the third trimester
Do not mix with alcohol or other NSAIDs
Tell your doctor about any kidney, liver, or heart problems
Inform your provider of all medications and allergies
Not recommended for people with ulcers or bleeding disorders
Use caution if over 65 due to higher risk of side effects
Toradol and Other Substances
Toradol can interact with many other substances, increasing the risk of side effects:
Other NSAIDs (like ibuprofen or naproxen): Raises risk of stomach bleeding
Blood thinners (like warfarin): Increases risk of serious bleeding
Diuretics (water pills): May reduce kidney function
ACE inhibitors and ARBs (for blood pressure): Can harm kidneys when combined
Steroids and oral steroids: Heightens risk of stomach ulcers
Serotonin norepinephrine reuptake inhibitors (SNRIs): May increase the risk of bleeding when combined with Toradol
Alcohol: Increases risk of stomach and liver damage
Natural Alternatives to Toradol for Pain Relief
For those looking to avoid Toradol, several natural options may help manage pain:
Turmeric (Curcumin): Anti-inflammatory properties
Ginger: May reduce pain and swelling
Omega-3 Fatty Acids: Found in fish oil; supports joint health
Willow Bark: Natural source of salicin, similar to aspirin
Capsaicin Cream: Topical relief for muscle and joint pain
Acupuncture: Can help reduce chronic pain
Heat and Cold Therapy: Simple, effective method for muscle and joint relief
Massage Therapy: Helps with tension and soreness
Talk to a healthcare provider before using natural remedies, especially if you take other medications.
Conclusion
Taking ketorolac for pain relief should be done under close medical supervision, and you should take ketorolac only as prescribed, especially if you have risk factors such as liver disease, heart failure, or a history of blood clots. Side effects like severe bleeding, tarry stools, dark urine, vomiting that looks like coffee grounds, unexplained weight gain, or cloudy urine may signal serious health problems. Contact your doctor immediately if you experience symptoms such as chest pain, wheezing, hoarseness, sore throat, hallucinations, sudden fainting, or blurred vision. Always take the correct dosage forms, never double up on a missed dose, and avoid alcohol while on this medication. Toradol can interact with many substances, and its effects may vary based on your condition, other medications, and overall health. Staying informed helps you safely manage pain while reducing the risk of dangerous reactions.
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FAQs
Nausea, dizziness, headache, upset stomach, and drowsiness are the most reported.
Yes. It can lead to stomach bleeding, kidney damage, high blood pressure, and allergic reactions, especially with long-term use.
Most mild side effects go away within a few hours to days after stopping the medication. Serious effects may last longer and need medical care.
Older adults, people with kidney or stomach issues, and those using it longer than 5 days face higher risks.
Stop taking the medication and contact your doctor, especially if symptoms are severe or do not go away. Seek emergency care for serious reactions.